• This book looks at some of the ignored aspects in the management of coronary artery disease associated with comorbid conditions. • Most chapters start with a prologue of real-life dilemmas that one encounters, and covers one condition per chapter. • In the middle part of the chapter, an extensive review of scarce literature available is discussed. • Most chapters conclude with an epilogue which gives some suggestions regarding management of an individual patient/comorbid condition. • The ACS with comorbid conditions discussed are the ones commonly encountered and yet pose challenge in management like ACS with stroke, with renal failure, with liver disease, with hematological disorders, etc.